Rat modeling and uric acid sustainability in hyperuricemic rats caused by potassium – oxonate

Published 20-09-2023
Section Research Articles

Authors

  • Smriti Verma Bharati Vidyapeeth homoeopathic medical College Pune
  • Dr. Sameer S. Nadgauda Assistant Professor, Department of Practice of Medicine, Bharati Vidyapeeth (Deemed to be University) Homoeopathic Medical College & Hospital , Pune – Satara Road- 411043, India
  • Dr. Pallavi Khatavkar Associate Professor, Department of Pharmacology, Bharati Vidyapeeth (Deemed to be University) Medical College & Hospital , Pune – Satara Road- 411043, India

DOI:

https://doi.org/10.7770/safer-V13N2-art726

Abstract

Hyperuricaemia is an important risk factor of CKD , metabolic syndrome and cardiovascular disease. We aimed to assess that for how much time uric acid levels sustains in wistar rats. A hyperuricemia mouse model was to be established by potassium oxonate (PO) administered by oral gavage and by intraperitoneal injections. In hyperuricemia rats, serum uric acid levels
increased but not significantly after oral administration for 7 days but administering PO intraperitoneally serum uric acid levels increased significantly after 1 hour but again returned within normal range after 2 hours. This paper presents method suitable for experimental hyperuricemia mouse model and shows the time feature of uric acid sustainability

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