Esta revisão abrangente da doença hepática gordurosa não alcoólica Nesta dislipidemia

Resumo

Background: Non-alcoholic fatty liver disease (NAFLD), also known as metabolic-associated fatty liver disease (MAFLD), is characterized by hepatocyte abnormal buildup of triglycerides and other lipids. This frequent illness can advance from simple steatosis to steatohepatitis and, ultimately, end-stage liver disease. MAFLD is linked to problems with systemic energy metabolism, such as insulin resistance and atherogenic dyslipidemia. The Scope Of Review: The liver is the primary organ in lipid metabolism because it secretes very low-density lipoproteins (VLDL) and internalizes fatty acids and lipoproteins. This review article highlights new findings on hepatic lipid synthesis, VLDL generation, and lipoprotein internalization in the context of MAFLD, as well as lipid exchange between adipose tissue and the liver. Major Conclusion: Triglycerides and other fats build up in the liver cells to cause fatty liver. The balance between the delivery and elimination systems determines the number of fatty acids in the liver. Inflammation of the liver and liver cell death has been linked to fatty liver in certain cases (steatohepatitis). The liver normally contains a specific quantity of fat, but when exposed to certain pathological circumstances, the balance between fat production and utilization may be disrupted. NAFLD dyslipidemia is characterized by elevated blood triglycerides, elevated tiny, dense low-density lipoprotein (LDL non-type A) particles, and decreased HDL cholesterol. In many areas of the globe, including the United States, nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver condition. According to population-based abdominal imaging studies, at least 25% of American people have fatty livers. The total frequency of NAFLD in the general population in India is near to 40%.